A massive blast rocked a Gaza City hospital packed with wounded and other Palestinians seeking shelter Tuesday, killing hundreds of people, the Hamas-run Health Ministry said. Hamas blamed an Israeli airstrike, while the Israeli military said the hospital was hit by a rocket misfired by Palestinian militants. 

The health ministry said at least 500 people had been killed. Video that The Associated Press confirmed was from the hospital showed fire engulfing the building and the hospital's grounds strewn with torn bodies, many of them young children. Around them in the grass were blankets, school backpacks and other belongings. 

The carnage came as the U.S. tried to convince Israel to allow the delivery of supplies to desperate civilians, aid groups and hospitals in the tiny Gaza Strip, which has been under a complete siege since Hamas' deadly rampage in southern Israel last week. It also came a day before President Joe Biden was due to visit the region to show support for Israel and try to prevent the war from spreading. 

Hundreds of Palestinians had taken refuge in al-Ahli and other hospitals in Gaza City in past days, hoping they would be spared bombardment after Israel ordered all residents of the city and surrounding areas to evacuate to the southern Gaza Strip. 

Hamas called Tuesday's hospital strike "a horrific massacre," saying it was caused by an Israeli strike. 

The Israeli military, however, said Palestinian militants had fired a barrage of rockets near the hospital at the time. "Intelligence from multiple sources we have in our hands indicates that Islamic Jihad is responsible for the failed rocket launch," it said. 

Ambulances and private cars rushed some 350 casualties from the al-Ahli blast to Gaza City's main hospital, al-Shifa, already overwhelmed with wounded from other strikes, said its director, Mohammed Abu Selmia. The wounded were laid onto bloody floors, screaming in pain. 

Wounded Palestinians wait for treatment, at the al-Shifa hospital, in Gaza City, central Gaza Strip, Tuesday, Oct. 17, 2023. Photo / AP

"We are squeezing five beds into a single tiny room. We need equipment, we need medicine, we need beds, we need anesthesia, we need everything," Abu Selmia said, warning that the fuel supply for the hospital's generators will run out Wednesday. "I think Gaza's medical sector will collapse within hours." 

Before the al-Alhi Hospital deaths, Israeli strikes on Gaza killed at least 2,778 people and wounded 9,700, according to the Gaza Health Ministry. Nearly two-thirds of those killed were children, a ministry official said. Another 1,200 people across Gaza are believed to be buried under the rubble, alive or dead, health authorities said. 

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Hamas' Oct. 7, attack in southern Israel killed more than 1,400 people, mostly civilians, and took some 200 captive into Gaza. Hamas militants in Gaza have launched rockets every day since, aiming at cities across Israel. 

In protest over the purported airstrike, Palestinian President Mahmoud Abbas cancelled his participation in a meeting with Biden, Jordan's King Abdullah II and Egypt's president set for Wednesday in Amman, Jordan to discuss the war. Abbas' Palestinian Authority runs parts of the West Bank. 

Hundreds of Palestinians flooded the streets of major West Bank cities including Ramallah, the seat of the Palestinian Authority, where protesters hurled stones at Palestinian security forces who fired back with stun grenades. Hundreds of people joined protests that erupted in Beirut and Amman, where an angry crowd gathered outside the Israeli Embassy. 

With tens of thousands of troops massed along the border, Israel has been expected to launch a ground invasion into Gaza — but plans remained uncertain. 

"We are preparing for the next stages of war," military spokesman Lt. Col. Richard Hecht said. "We haven't said what they will be. Everybody's talking about a ground offensive. It might be something different." 

Throughout the day Tuesday, airstrikes killed dozens of civilians and at least one senior Hamas figure in the southern half of the Gaza Strip, where the Israeli military had told Palestinians to evacuate to. An Associated Press reporter saw around 50 bodies brought to Nasser Hospital after strikes in the southern city of Khan Younis. 

Palestinians look for survivors after an Israeli airstrike on Khan Younis, Gaza Strip, Tuesday, Oct. 17, 2023. Photo / AP

An airstrike in Deir al Balah reduced a house to rubble, killing a man and 11 women and children inside and in a neighboring house, some of whom had evacuated from Gaza City. Witnesses said there was no warning before the strike. 

Shelling from Israeli tanks hit a U.N. school in central Gaza where 4,000 Palestinians had taken refuge, killing six people and wounding dozens, the United Nations Palestinian refugee agencysaid. At least 24 U.N. installations have been hit the past week, killing at least 14 of the agency's staff. 

The Israeli military said it was targeting Hamas hideouts, infrastructure and command centers. 

A barrage of strikes crashed into the Bureij refugee camp in central Gaza, leveling an entire block of homes and causing dozens of casualties among families inside, residents said. Among those killed was one of Hamas' top military commanders, Ayman Nofal, the group's military wing said — the most high-profile militant known to have been killed so far in the war. 

Nofal, formerly the intelligence chief of Hamas' armed wing, was in charge of Hamas militant activities in the central Gaza Strip, including coordinating activities with other militant groups. 

Netanyahu sought to put the blame on Hamas for Israel's retaliatory attacks and the rising civilian casualties in Gaza. "Not only is it targeting and murdering civilians with unprecedented savagery, it's hiding behind civilians," he said. 

In Gaza City, Israeli airstrikes also hit the house of Hamas' top political official, Ismail Haniyeh, killing at least 14 people. Haniyeh is based in Doha, Qatar, but his family lives in Gaza City. The Hamas media office did not immediately identify those killed. 

With Israel barring entry of water, fuel and food into Gaza since Hamas' brutal attack last week, U.S. Secretary of State Antony Blinken secured an agreement with Israeli Prime Minister Benjamin Netanyahu to discuss creation of a mechanism for delivering aid to the territory's 2.3 million people. U.S. officials said the gain might appear modest, but stressed that it was a significant step forward. 

Still, as of late Tuesday, there was no deal in place. A top Israeli official said Tuesday his country was demanding guarantees that Hamas militants would not seize any aid deliveries. Tzahi Hanegbi, head of Israel's National Security Council, suggested entry of aid also depended on the return of hostages held by Hamas. 

"The return of the hostages, which is sacred in our eyes, is a key component in any humanitarian efforts," he told reporters, without elaborating. 

More than 1 million Palestinians have fled their homes — roughly half of Gaza's population — and 60% are now in the approximately 14-kilometer (8-mile) long area south of the evacuation zone, the U.N. said. 

An Israeli soldier inspects a house damaged by Hamas militants in Kibbutz Be'eri, Israel on October 17. The kibbutz was overrun by Hamas militants on October 7. Photo / AP

Aid workers warned that the territory was near complete collapse. Hospitals were on the verge of losing electricity, threatening the lives of thousands of patients, and hundreds of thousands of people searched for bread and water. 

The U.N. agency for Palestinians said more than 400,000 displaced people are crowded into schools and other facilities in the south with little food or water. 

Israel opened a water line into the south for three hours that benefitted only 14 percent of Gaza's population, the U.N. said. 

At the Rafah crossing, Gaza's only connection to Egypt, truckloads of aid were waiting to enter. The World Food Program said that it had more than 300 tons of food waiting to cross into Gaza. Civilians with foreign citizenship — many of them Palestinians with dual nationalities — also waited in Rafah, desperate to get out. 

Repeated reports that an opening was imminent have proven false as negotiations continued to grind on, including the U.S., Israel and Egypt. 

A senior Egyptian official called it a "very tough, complicated back-and-forth process" and said talks were over deliveries through Rafah and Israel's Karam Shalom crossing to Gaza. He said Israel was insisting to search all aid, and wants to "ensure that such aid won't benefit Hamas." He said Egypt proposed that the U.N. oversee the whole process, including inside Gaza. The official spoke on condition of anonymity because he was not allowed to brief the press on the talks. 

Officials for Hamas and Israel cast doubt on an immediate opening, saying they were unaware of an agreement. 

Biden's visit in part aims to prevent the war from sparking a broader regional conflict. Violence flared Tuesday along Israel's border with Lebanon, where Iranian-backed Hezbollah militants operate. 

Israel evacuated towns near its northern border with Lebanon, where the military has exchanged fire repeatedly with Hezbollah militants. 

Israel said it killed four militants wearing explosive vests who were attempting to cross into the country from Lebanon on Tuesday morning. No group immediately claimed responsibility. 

Iran's Supreme Leader Ayatollah Ali Khamenei warned that Israel's continuing offensive in Gaza could cause a violent reaction across the region. 

"Bombardments should be immediately stopped. Muslim nations are angry," Khamenei said, according to state media. 

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-NAJIB JOBAIN, SAMYA KULLAB, RAVI NESSMAN, and MATTHEW LEE, Associated Press 

Kullab reported from Baghdad. Nessman reported from Jerusalem. Lee reported from Amman. Associated Press journalists Amy Teibel in Jerusalem; Abby Sewell in Beirut; Samy Magdy and Jack Jeffrey in Cairo; and Ashraf Sweilam in el-Arish, Egypt contributed to this report.