The Big Bang Theory, one of the most-watched shows in the U.S., will wrap up next year after its 12th season, bringing an end to television's longest-running multi-camera comedy.

The sitcom, created by producers Chuck Lorre and Bill Prady, blossomed from a minor hit when it debuted in 2007 to the most-watched comedy on TV in certain years.

It was the second-most-watched comedy in America this year, trailing only the Roseanne reboot.

The show has also been well-received by the industry, earning 52 Emmy nominations and 10 wins.

The Big Bang Theory has been an anchor for CBS, the most-watched U.S. TV network, and its absence will force the network to look for a new hit. CBS and Warner Bros., the studio that produces the sitcom, have already created a spinoff, Young Sheldon, about one of the main characters as a child.

While The Big Bang Theory got more expensive as the years wore on - and the stars were able to demand more money for each season - Warner Bros. has made a small fortune selling the rights to reruns. The final season debuts Sept. 24.